Marco Santelli

@Marco

I work at the intersection of autonomous systems, knowledge and information behaviour, and business processes — with the human firmly at the centre.

At seven, I took apart my first electronic device to see how it worked. The instinct never left. I spent twenty-five years building engineering teams across countries and wrote a dissertation on the value that lives between people. Now software is becoming an actor, not a tool — and I am trying to find out, in two ventures and in writing, what happens to that value when machines mediate the work that holds organisations together.


The work

I have never paid much attention to company names or the titles assigned to me. The path went from HR consulting in the nineties to movie production, then high-tech R&D and CTO positions across regulated and non-regulated industries, then back to consulting — fractional CTO, head of engineering, strategic advisor. There is no tidy progression. I followed whatever I was in love with at the time, and the titles followed me, not the other way around.

Along the way I launched seventy-two digital products. Some got replaced. Some are still in use after ten years. Some got improved and transformed in line with how their industries changed. You have probably used a few of them, or still are. The number that matters to me is not seventy-two — it is the number of times something failed and I learned why, or something succeeded and I learned not to assume it would again.

The thing I care about most is simpler than any of it. Every person I have worked with over thirty years is still willing to work with me again. That has mattered more to my career than anything I have built.


The domains

Most of my career has run through regulated industries — healthcare, biotech, supply chain R&D, financial services — where data governance, privacy, and compliance are not features you add later but the core architectural problem. I have designed hospital networks connecting eighteen facilities with a total reach of four million patients a year, built AI pipelines for drug screening in malaria research, and scaled platforms to eighty thousand concurrent users in environments where a single compliance failure is not an acceptable trade-off. I have also worked across media, agriculture, and mobility, usually brought in to figure out what the technology strategy should actually be before anyone starts building.


What I studied

I have a bachelor's in business administration, an executive MBA from the Polytechnic of Milan focused on digital transformation, and a postgraduate program in AI and machine learning from Caltech. I hold a financial modelling and valuation analysis certification, along with Prince2, COBIT, ITIL, and the usual project management credentials. I am currently pursuing a degree in biology with a specialisation in bioengineering and neuroscience — because the gap between what I know about systems and what I do not yet know about the biological ones is bothering me in the same way the gap between technology and people did ten years ago. I have one peer-reviewed publication, on machine learning for phenotypic imaging in malaria research, indexed on PubMed.


What I am building


A few personal notes

I was born in Italy, lived in Britain for twenty-one years, spent two in Norway - back and forth, and have been in Switzerland for three. The longer I stay anywhere the harder it becomes to give a tidy answer to where I am from.

I read more than is good for me, mostly things outside my own field. I have a soft spot for cosmology and for the older branches of philosophy of science, and a less defensible soft spot for spiking neural networks, which I keep meaning to do something serious with and have not yet. I am skeptical of most management advice and most thought leadership, including, on bad days, some of my own.


Get in touch

I am open to advisory work, fractional CTO engagements, speaking, and conversations with people working on problems that overlap with the ones I care about. If something on this page resonated, the easiest way to reach me is through LinkedIn.


For the longer version — the journey.